Thursday, 13th February

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Speakers

1:55PM - 2:00PM

Novartis Lecture Theatre

2:00PM - 3:00PM

Thursday, 13th February

Novartis Lecture Theatre

Chair: David Huang

The critical role of Extracellular Matrix and Microenvironment in metastasis and dormancy - Mina Bissell

3:00PM - 4:00PM

Thursday, 13th February

Exhibition Hall

4:00PM - 6:00PM

Thursday, 13th February

Novartis Lecture Theatre

Chair: Ruth Ganss

Not available - Valerie Marie Weaver
Targeting the proangiogenic and immunosuppressive tumour microenvironment in primary and metastatic breast cancer - Roberta Mazzieri
Therapeutic targeting of EphA3 inhibits cancer growth by disrupting the tumor microenvironment. - Martin Lackmann
IAPs and RIPKs modulate sensitivity to TNF induced apoptosis and cancer formation - W. Wei-Lynn (Lynn) Wong
Not available - Xiaodong Wang

6:20PM - 7:30PM

Thursday, 13th February

Seagrass Lawn

7:30PM - 10:00PM

Thursday, 13th February

Exhibition Hall

Gamma camera imaging of small animals injected with ¹⁷⁷Lu-MDP, ¹⁷⁷Lu-PYP and ¹⁷⁷Lu-HA with potentials to be used for the treatment of bone cancer and rheumatoid arthritis - Imtiaz A Abbasi
Inhibition of Tumour Angiogenesis as a means to reduce cancer growth by novel Benzoaxines - Sara Al-Rawi
Identification of Chromosomal Aberrations Using Fluorescence In Situ Hybridization (Fish) And Drug Metabolizing Gene Polymorphism (Gst, Cyp) In Prostate Cancer Patients of South Indian Region, India. - karthick kumar alagamuthu
Molecular Evaluation of Anti-Proliferative Effect of (Cichorium endivia, L.) Extracts On the Growth of Hepatocellular Carcinoma - Ali Alshehri
POT1 mutations predispose to familial melanoma - Lauren G Aoude
IT’S A HIT: THE ACRF DRUG DISCOVERY CENTRE - Greg M Arndt
Induction of Apoptosis by Fucoidan in Human Acute Promyelocytic Leukaemia cells - Farzaneh F Atashrazm
Cyclin-dependent kinase inhibitor, Dinaciclib induces anti-tumour activity of mixed-lineage leukemia-AF9 surpassing known targeted therapies for this disease. - Adele J Baker
Autophagy-related genes act as tumour suppressors in cooperation with oncogenic Ras to promote epithelial tumourigenesis in Drosophila - Sangita Banerjee
The oncofetal protein, Insulin-like growth factor 2 mRNA-binding protein 1 has Increased DNA Copy Number, mRNA, and Protein Expression in High-risk Neuroblastoma - Jessica Bell
Role of the transcription factor Id4 in the developing mammary gland - Sarah Best
Characterisation of ADAMTS15: a potential tumour suppressor gene in Prostate cancer - Marley J Binder
Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis. - Gavin D Brooks
Using a novel mouse model of colitis to study the impact of different oncogenic mutations on intestinal tumourigenesis - Michael Buchert
NFKBIA (IkBα) mediates prostate cancer cell death induced by combination treatment with vorinostat and bicalutamide - Lisa M Butler
Drugging the undruggable in the clinic: a Phase I trial for RNA Polymerase I inhibitor CX-5461 in haematological malignancies - Don P Cameron
Genome wide RNAi screen to identify regulators of the oncoprotein LMO4. - Bianca Capaldo
Arsenic-induced differential protein changes in rat uroepithelial cells - Chee-Yin Chai
The Ubiquitin Ligase Siah is a novel regulator of Zeb1 in Breast Cancer - Anna Chen
Differential expression analysis of RNA-seq data using edgeR and limma - Yunshun Chen
Profiling the evolution of malignant melanoma - Vincent D Corbin
DNA based immunotherapy in triple negative metastatic breast cancer - Ryan Cross
Mutations in GRIN2A correlate with reduced survival of melanoma patients - Stacey N D'mello
Continuous low-dose estrogen supplementation can sustain MCF7 tumour growth with no estrogen-related toxicity - Genevieve Dall
The development of novel peptide based drugs for the treatment of sonic hedgehog dependent medulloblastoma and other cancers. - Peter B Dallas
A transcriptional role for cohesin in breast cancer - Tanushree Dasgupta
Snail2 inhibits terminal differentiation by directly down-regulating the serine proteinase, matriptase-1 - Naomi C Delic
Elucidating the mechanism by which novel anti-tropomyosin compounds induce neuroblastoma cell death - Melissa Desouza
Combined inhibition of ribosome biogenesis and ribosome function cooperate to extend survival in MYC-driven B-cell lymphoma - Jennifer R Devlin
GPR84 drives beta-catenin expression in leukaemic stem cells to maintain acute myeloid leukaemia - Philipp A Dietrich
PG545, a heparan sulfate mimetic, targets the tumour microenvironment to potently inhibit solid tumour growth and metastasis, alone and in combination with chemotherapy, in models of pancreatic and ovarian cancer. - Keith Dredge
How do cancer cells become aneuploid? - Pascal HG Duijf
The role of myoepithelial proteins in blocking breast cancer invasion - Hendrika M Duivenvoorden
Immune cell infiltration is associated with resistance to endocrine therapy in oestrogen receptor positive breast cancers - Anita K Dunbier
Adoptive immunotherapy utilising chimeric receptors identified using a DNA library approach - Connie PM Duong
Functional studies of cysteine cathepsin activity in breast cancer metastasis - Laura E Edgington
The role of Deubiquitinating Enzymes in the TGFB pathway - Pieter Eichhorn
Histological and molecular profiling of dividing cells in cancer using EdU - Berwini Endaya
TRAF2 regulates canonical and non canonical NFĸB pathways to inhibit cell death and inflammation in skin. - Nima Etemadi
Cell death mediates perinatal lethality in RIPK1 knockout mice - Joseph M Evans
Targeting epigenetically driven leukaemias through inhibition of the acetyltransferase monocytic leukaemia zinc finger protein (MOZ) - Hendrik Falk
A genome-wide screen for novel genes involved in sensitisation to histone deacetylase inhibitors - Katrina J Falkenberg
Highly metastatic MDA-MB-231 breast tumour cells: altered migratory potential and sensitivity to glucocorticoids? - Ebony R Fietz
Yes-associated protein (YAP) regulates transcriptional coactivator with PDZ-binding motif (TAZ) abundance to rescue proliferation of liver progenitor cells. - Megan Finch
Localized synchrotron radiation affects serum cytokine levels and modulates gene expression in irradiated mouse skin and in skin distant from the irradiated site. - Helen B Forrester
Elf5: double-edged sword for breast cancer metastasis - David Gallego Ortega
E6AP acts through E2F1 to suppress the INK4/ARF locus: implications for NSCLC - Cristina Gamell
Molecular Analysis of Circulating Tumour Cells (CTCs) from the Blood of Patients with Colorectal Cancer (CRC) detected with the CellSearch System - Christin Gasch
A PR55a-containing PP2A complex positively regulates Fra-1/c-Jun function in tumour cells - Omer Gilan
The asymmetric cell division regulator GPSM2 controls mammary progenitor activity and breast cancer progression. - Nathan Godde
Oncogenic H-Ras induced epithelial-mesenchymal transition (EMT) of Madin-Darby canine kidney (MDCK) cells: functional insights into released extracellular vesicles - Shashi Gopal
REGULATION OF PD-L1 EXPRESSION IN HUMAN MELANOMA BY NF-kB - Kavitha Gowrishankar
Retinoic Acid Receptor (RAR) agonists maintain bi-potency of mesenchymal progenitor cells in vitro - Alanna C Green
The oncogenic functionality of JAK2 and PD-L1 to Eµ-Myc lymphoma - Gareth Gregory
Efficacy of allosteric MK2 inhibitors as single agents in glioblastoma cells - Fadi Gurgis
Patterns of care for women with invasive endometrial cancer – results from the population-based Australian National Endometrial Cancer study - Alison M Hadley
Zeb2 Drives T-cell Lymphoblastic Leukemia Development Via Altered IL-7 Receptor Signaling And Enhanced Tumor-Initiating Potential - Jody Haigh
Targeted Genome Sequencing Reveals Mitochondrial Mutations Driving Metabolic Adaptation in Pancreatic Cancer. - Rae-Anne Hardie
Heterozygous expression of an oncogenic Pik3ca mutation during murine development results in fatal embryonic and extraembryonic defects - Lauren M Hare
Inhibition of Cancer Invasion by PAI-2/SerpinB2, a Specific Regulator of Urokinase Plasminogen Activator - Nathanial L Harris
Exploring Mdmx Inhibition as a novel Breast Cancer Therapy - Sue Haupt
A role for E6AP in cellular senescence by regulating the p53/INK4-ARF pathways - Ygal Haupt
Investigation of tryptophan metabolism in various human breast cancer subtypes - Benjamin R Heng
Improving targeted therapy in oncogene expressing High-Grade Serous Ovarian Cancer using novel xenografts - Valerie Heong
Characterising mechanisms of apoptosis induction by BET-bromodomain inhibition in aggressive Myc-driven lymphoma - Simon Hogg
Combined Wnt/β-catenin, Met and CXCL12/CXCR4 Signals Characterize Basal Breast Cancer and Predicts Disease Outcome - Jane D Holland
Enriched expression of the nuclear receptor PXR (NR1I2) drives colon Tumour-Initiating Cell resistance to chemotherapy. - Fred Hollande
Nanotechnology to Fight Ovarian Cancer (Synthesis to in-vivo Study) - Lubna Hossain
Dual targeting of hypoxia and homologous recombination repair defects for cancer therapy - Francis W Hunter
Glaucarubinone Inhibited Colorectal Cancer Growth by Down-Regulation of p21- Activated Kinase 1. - Nhi Huynh
Defining the Role of E3 Ubiquitin Ligase UBR5 in Cancer Through Substrate Identification - Mary Iconomou
Gain-of-function Lyn induces anemia – appropriate Lyn activity is essential for normal erythropoiesis and Epo-receptor signaling. - Evan Ingley
The interaction of cisplatin and related novel drug analogues with DNA containing telomeric repeat sequences - Ben Johnson
Modeling myelodysplastic syndromes in mice by altered Hoxa1 spliceform expression - Chacko Joseph
INTRAVITAL IMAGING REVEALS TUMOUR-ASSOCIATED macrophages as targets of bisphosphonateS IN VIVO - Simon Junankar
Investigating the role of Pim-1 kinase in breast cancer brain metastasis - Lara Jupp
Amino acids increase RNA polymerase I transcription through mTORC1 and MYC signaling pathways - Jian Kang
Quantitative Analysis and Mathematical Modeling of the Effects of Cytokine Signalling on Epithelial Cells - Shabnam Khatibi
Evaluation of Novel HDAC Inhibitors against Mouse and Human Brain Metastatic Breast Cancer In Vitro and In Vivo - Soo Hyun Kim
The NSAID sulindac activates pro-inflammatory NF-kB and AP-1 signalling but also causes apoptosis of colon cancer cells. - Maija RJ Kohonen-Corish
ALLOCATE: sorting ovarian cancer patients into treatment arms based on molecular and genetic make up of their tumours. - Olga Kondrashova
Tumor Initiating Cells and Chemoresistance in Colorectal Cancer - E. Louise Lagerqvist
Understanding the role of the Bcl-2 family member Bcl-G in inflammation-associated colon cancer - Nga Lam
Defining the role of ZEB1 in the pathogenesis of non-small cell lung cancer (NSCLC) using immortalized human bronchial epithelial cells (HBECs) - Jill E Larsen
Chronic stress promotes lymph node metastasis through beta-adrenergic regulation of lymphangiogenesis - Caroline P Le
TIE2 expressing monocytes: Investigating their protumoural and prometastatic activities - Shannon Jing Yi Lee
Exome sequencing reveals Bcl6 co-repressor (Bcor) as a frequently mutated tumor suppressor gene in Eμ-Myc lymphoma - Marcus Lefebure
BL-011256 is a novel VEGFR3 selective inhibitor, which suppresses tumour lymphatics and lymph node metastasis in an animal model of melanoma - Annabell Leske
Targeting a novel epigenetic oncogene required for the maintenance of acute myeloid leukaemic stem cells - Halina Leung
Sorting nexin 5 (SNX5) is a regulator of the macropinocytic pathway. - Jet Phey Lim
Towards a structural understanding of the cell polarity regulator and tumour suppressor protein, Scribble - Krystle Lim
POLO-LIKE KINASE 1 AS A BIOMARKER IN RECTAL CANCER -
Circulating microRNAs associated with chemotherapy outcome of prostate cancer - Hui-Ming Lin
Methods and data analysis tools for sequencing ribosome protected mRNA fragments - Leah Alcock

Friday →

Thursday, 13th February 26th Lorne Cancer Conference 2014

Welcome

Session 1: Plenary

Afternoon Tea

Session 2: Tumour microenvironment

Welcome BBQ

Poster Session 1