Sue Haupt
PERSONAL PROFILE
• Senior Research Fellow (PhD) at the Peter MacCallum Cancer Centre.
• Over the past decade I have made key contributions to the understanding of the mechanisms and regulation of tumour suppression, with a focus on mutant forms of the major Tumour Suppression TP53.
• My current research focusses on cancer sex-disparity. I discovered a role for TP53 and the X-chromosome in sex-disparity in non-reproductive cancers
• My research spans from basic research to novel therapeutics, utilising bioinformatics approaches, human samples, sophisticated mouse and cell culture experimental models.
KEY RESEARCH PUBLICATIONS 2019-2020
I have published 82 articles: 35% (17/49) of my research papers and 36% (12/33) of my reviews were published over the last 5 years
1. #HAUPT S, ..…et.al., Haupt Y. (2019) Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network. Nature Communications. 10: 5385.
2. # Delbridge A.R.D. ….. HAUPT S, et.al., Voss, A.K (2019) Loss of p53 causes stochastic aberrant X-chromosome inactivation and female-specific neural tube defects. Cell Reports, 27(2): 442-454.
3. #Fortuno C, Cipponi A, Ballinger ML, et.al., HAUPT S, et.al., James PA. (2019) A quantitative model to predict pathogenicity of missense variants in the TP53 gene. Hum Mutat, 40: 788-800.
4. #Cao L, …. et.al., HAUPT S, …. Oesterreich S, Atkinson JM. (2019) Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma. Cancer Lett. 461:21-30.
5. AbuHammad S et.al., HAUPT S, et.al., GA, Sheppard KE. (2019) Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma. Proc Natl Acad Sci USA. 116:17990-18000.
6. #Gamell C, et.al., HAUPT S, Richardson DR, Haupt Y. (2019) E6AP Promotes a Metastatic Phenotype in Prostate Cancer. iScience. 22: 1-15.
7. #Keam, S.P et.al., HAUPT S, …. Paul J Neeson. (2020) High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot. J. Immunother. Cancer. 8: e000792.
8. #Freudenstein D et al… Haupt Y, HAUPT S (2020) TP53 status, patient sex, and the immune response as determinants of lung cancer patient survival. Cancers 12: E1535.
9. Keam, S.P. et.al., HAUPT S,…., Neeson PJ. High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot. J Immunother Cancer (2020) 8(1):e000792.
10. # Portman N, et.al., ..HAUPT S, Haupt Y,….Lim E. (2020) MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer. Breast Cancer Res 22(1):87
PUBLIC PROFILE
• 2019: Invited interview with Dr Norman Swan on the Health Report on ABC RN Radio; https://www.abc.net.au/radionational/programs/healthreport/sex-differences-in-cancer/11757050
• 2019: Interviewed by 3AW radio
• 2109: Herald-Sun research featured (page 3 Bridget O’Connell, 2019.11.27); The Daily Telegraph; The Courier Mail; NT News, Geelong Advertiser; TheAdvertiser; SCIMEX;Medical Press
INVITED ORAL PRESENTATIONS 2019
• P53 isoforms meeting, Croatia
• Sechuan University, China
• University of Trieste, Italy
• National Cancer Institute Regia Elena of Rome, Italy,
• Weizmann Institute of Science, Israel